桑福德（约翰·库萨克 John Cusack 饰）是一名精神病医生，在治愈他人疾病的同时，桑福德自己的家庭却伤痕累累。儿子本杰（伊万·伯德 Evan Bird 饰）年纪轻轻却因为吸毒而被关进了戒毒所，女儿阿加莎（米娅·华希科沃斯卡 Mia Wasikowska 饰）更糟，她竟然因为纵火而被关入了精神病院。
不仅家庭生活陷入了困境，桑福德的事业亦走到了瓶颈，哈瓦那（朱丽安·摩尔 Julianne Moore 饰）是桑福德的病人，亦是一名演员，她生活在同为著名演员的母亲的阴影之下，甚至连做梦也被母亲的幻影所纠缠。阿加莎出院了，本杰亦回归了家庭之中，孩子们的归来带给桑福德的是更大的麻烦，和更混乱的生活。
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朱丽安·摩尔,米娅·华希科沃斯卡,罗伯特·帕丁森,约翰·库萨克,莎拉·加顿,凯丽·费雪,奥莉维亚·威廉姆斯,妮娅姆·威尔逊,艾米利亚·麦卡锡,埃文·伯德,阿曼达·布鲁盖尔,珍妮·海特梅亚,乔纳森·沃顿
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